The 100th anniversary of World War I is a reminder of the risks of great power politics. The current dynamics of world politics rest on the relations among the US, China, Russia and India, and their interlocking relations with friends and enemies in a region that extends from the Gulf to the Japanese archipelago. A naval and nuclear arms race is underway that reflects these complex relationships. One of the numerous disputes could spread conflict across the whole region. This risk includes the nuclear factor. A three-pronged effort including political detente, arms control and nuclear disarmament is needed to defuse these dangers, which will otherwise continue to grow.