The stunning British vote of June 24, 2016, to quit the European Union (EU)—dubbed Brexit—has triggered a major realignment of economic and political forces across the globe, strengthening the template of a new world order tilted towards Moscow, Beijing and the rising powers of Asia and Africa. As Washington nervously recognizes, there will be a decline in the influence of the US, EU and North Atlantic Treaty Organization (NATO), the latter two having served as instruments of US global domination.